Circadian clocks, brain function, and development
Identifieur interne : 006132 ( Main/Exploration ); précédent : 006131; suivant : 006133Circadian clocks, brain function, and development
Auteurs : Ellen Frank [États-Unis] ; Michelle M. Sidor [États-Unis] ; Karen L. Gamble [Royaume-Uni] ; Chiara Cirelli ; Katherine M. Sharkey [États-Unis] ; Nathaniel Hoyle [Royaume-Uni] ; Liat Tikotzky [Israël] ; Lisa S. Talbot [États-Unis] ; Michael J. Mccarthy [États-Unis] ; Brant P. Hasler [États-Unis]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2013-12.
Descripteurs français
- Wicri :
- topic : Génétique.
English descriptors
- KwdEn :
- Acad, Adhd, Affective, Agomelatine, Amygdala, Antidepressant, Bidirectional, Biol, Bipolar, Bipolar disorder, Bmal1, Brain function, Carskadon, Circadian, Circadian clock, Circadian clocks, Circadian cycle, Circadian factors, Circadian genes, Circadian period, Circadian rhythms, Circadian system, Clock genes, Conditionality, Depressive, Deprivation, Entrainment, Epigenetic, Feedback loop, Fetal, Gene expression, Genetics, Gwas, Lithium, Major depressive disorder, Melatonin, Mood disorders, Mutant, Mutation, Natl, Ndings, Neurosci, Oscillator, Overview, Per2, Phenotype, Proc, Psychopathology, Receptor, Robust, Robustness, Sadeh, Suprachiasmatic, Suprachiasmatic nucleus, Synaptic, Takahashi, Transcriptional, York academy, Young adults.
- Teeft :
- Acad, Adhd, Affective, Agomelatine, Amygdala, Antidepressant, Bidirectional, Biol, Bipolar, Bipolar disorder, Bmal1, Brain function, Carskadon, Circadian, Circadian clock, Circadian clocks, Circadian cycle, Circadian factors, Circadian genes, Circadian period, Circadian rhythms, Circadian system, Clock genes, Conditionality, Depressive, Deprivation, Entrainment, Epigenetic, Feedback loop, Fetal, Gene expression, Genetics, Gwas, Lithium, Major depressive disorder, Melatonin, Mood disorders, Mutant, Mutation, Natl, Ndings, Neurosci, Oscillator, Overview, Per2, Phenotype, Proc, Psychopathology, Receptor, Robust, Robustness, Sadeh, Suprachiasmatic, Suprachiasmatic nucleus, Synaptic, Takahashi, Transcriptional, York academy, Young adults.
Abstract
Circadian clocks are temporal interfaces that organize biological systems and behavior to dynamic external environments. Components of the molecular clock are expressed throughout the brain and are centrally poised to play an important role in brain function. This paper focuses on key issues concerning the relationship among circadian clocks, brain function, and development, and discusses three topic areas: (1) sleep and its relationship to the circadian system; (2) systems development and psychopathology (spanning the prenatal period through late life); and (3) circadian factors and their application to neuropsychiatric disorders. We also explore circadian genetics and psychopathology and the selective pressures on the evolution of clocks. Last, a lively debate is presented on whether circadian factors are central to mood disorders. Emerging from research on circadian rhythms is a model of the interaction among genes, sleep, and the environment that converges on the circadian clock to influence susceptibility to developing psychopathology. This model may lend insight into effective treatments for mood disorders and inform development of new interventions.
Url:
DOI: 10.1111/nyas.12335
Affiliations:
- Israël, Royaume-Uni, États-Unis
- Angleterre, Californie, Midlands de l'Ouest, Pennsylvanie, Rhode Island
- Birmingham, Pittsburgh, Providence (Rhode Island), San Diego, San Francisco
- Université Brown
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 003617
- to stream Istex, to step Curation: 003617
- to stream Istex, to step Checkpoint: 000E89
- to stream Main, to step Merge: 006477
- to stream Main, to step Curation: 006132
Le document en format XML
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<term>Agomelatine</term>
<term>Amygdala</term>
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<term>Bidirectional</term>
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<term>Circadian clock</term>
<term>Circadian clocks</term>
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<term>Circadian period</term>
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<term>Circadian system</term>
<term>Clock genes</term>
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<term>Depressive</term>
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<term>Entrainment</term>
<term>Epigenetic</term>
<term>Feedback loop</term>
<term>Fetal</term>
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<term>Major depressive disorder</term>
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<term>Mutant</term>
<term>Mutation</term>
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<term>Ndings</term>
<term>Neurosci</term>
<term>Oscillator</term>
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<term>Phenotype</term>
<term>Proc</term>
<term>Psychopathology</term>
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<term>Depressive</term>
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<front><div type="abstract">Circadian clocks are temporal interfaces that organize biological systems and behavior to dynamic external environments. Components of the molecular clock are expressed throughout the brain and are centrally poised to play an important role in brain function. This paper focuses on key issues concerning the relationship among circadian clocks, brain function, and development, and discusses three topic areas: (1) sleep and its relationship to the circadian system; (2) systems development and psychopathology (spanning the prenatal period through late life); and (3) circadian factors and their application to neuropsychiatric disorders. We also explore circadian genetics and psychopathology and the selective pressures on the evolution of clocks. Last, a lively debate is presented on whether circadian factors are central to mood disorders. Emerging from research on circadian rhythms is a model of the interaction among genes, sleep, and the environment that converges on the circadian clock to influence susceptibility to developing psychopathology. This model may lend insight into effective treatments for mood disorders and inform development of new interventions.</div>
</front>
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